Eighth seed David Ferrer has pulled out of Wimbledon with an elbow injury.
He was set to play Britain’s James Ward, 28, in the first round, but will be replaced by a lucky loser from qualifying, Italy’s Luca Vanni.
World number seven Ferrer, 33, reached the quarter-finals at SW19 in 2013.
His exit opens up the draw for Rafael Nadal, who could have faced his fellow Spaniard in the fourth round, with a potential quarter-final against Britain’s Andy Murray for the winner.
Wimbledon begins on Monday, with defending men’s champion Novak Djokovic opening play on Centre Court against Germany’s Philipp Kohlschreiber at 13:00 BST.